This review aims to address the connection between EVs and mental disorders, and discuss the current strategies that focus on EVs-related psychiatric detection and therapy. Therefore, underlying the downstream functions of EVs and their cargo may help uncover the pathogenetic mechanisms of mental disorders as well as provide novel biomarkers and therapeutic candidates. For many years, interest has been generated in exploring new diagnostic and therapeutic methods for mental disorders, but scale assessment and routine drug intervention are still the first-line applications so far. In addition, studies have found that some cargo of EVs, especially miRNAs, were significantly up- or down-regulated in patients with mental disorders. To date, known characteristics of mental disorders are mainly neuroinflammation and dysfunctions of homeostasis in the CNS, and EVs are proven to be able to regulate these pathological processes. File import instruction AbstractĮxtracellular vesicles (EVs) are nanoscale particles with various physiological functions including mediating cellular communication in the central nervous system (CNS), which indicates a linkage between these particles and mental disorders such as schizophrenia, bipolar disorder, major depressive disorder, etc. Select the file that you have just downloaded and select import option Reference Manager (RIS). Extracellular Vesicles in Mental Disorders: A State-of-art Review. Kong L, Zhang D, Huang S, Lai J, Lu L, Zhang J, Hu S. Jianbo Lai, Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Email: laijianboedu.cn. Lin Lu, Institute of Mental Health/National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Peking University, Beijing 100191, China Email: linluedu.cn. Jing Zhang, Department of Pathology, First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China. ✉ Corresponding authors: Shaohua Hu, Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Email: dorhushaohuaedu.cn. National Health and Disease Human Brain Tissue Resource Center, Zhejiang University, Zhejiang, China. Department of Pathology, First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.ĩ. Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.Ĩ. Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No.2018RU006), Peking University, Beijing, China.ħ. Department of Neurobiology, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brian Medicine, and MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University School of Medicine, Hangzhou 310003, China.Ħ. Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou 310003, China.ĥ. Brain Research Institute of Zhejiang University, Hangzhou 310003, China.Ĥ. The Key Laboratory of Mental Disorder's Management in Zhejiang Province, Hangzhou 310003, China.ģ. Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.Ģ. Review Extracellular Vesicles in Mental Disorders: A State-of-art Review
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